課程資訊
課程名稱
基因體研究特論
Special Topics in Genomic Studies 
開課學期
108-1 
授課對象
公共衛生學院  流行病學與預防醫學研究所  
授課教師
郭柏秀 
課號
EPM7181 
課程識別碼
849 M0750 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
公衛209 
備註
與張弘潔、林菀俞、盧子彬合授
限碩士班以上
總人數上限:15人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1081EPM7181_ 
課程簡介影片
 
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課程概述

The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. We’ll cover topics related to a) Study design, data analysis and integration; b) Assessment of human genome variation and regulation; c) Using genomic information in medicine and public health; and d) Ethical issues in using genomic data. 

課程目標
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies.
 
課程要求
[具備基礎遺傳學知識,或修習過遺傳流行病學原理、其他授課教師認可之遺傳相關課程]
Class participation: including presentation and discussion.
Assignments: written discussion about the designated questions listed in each session.
Final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field.
 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
 
參考書目
Human Genome Epidemiology, 2nd Edition

Building the evidence for using genetic information to improve health and
prevent disease.

Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Final report 
30% 
 
2. 
Class assignments 
20% 
 
3. 
Class participation 
50% 
 
 
課程進度
週次
日期
單元主題
第1週
09/11  Epigenetics, chromatin structure and diseases 
第2週
09/18  Course introduction and introduction of genomic epidemiology 
第3週
09/25  ASPPH系列國際研討會教育週 
第4週
10/02  Genome-wide association studies 
第5週
10/09  Pharmacogenomics 
第6週
10/16  Risk prediction & causal variants 
第7週
10/23  Roles of non-coding variants 
第8週
10/30  Rare variants introduction 
第9週
11/06  GE-interaction 
第10週
11/13  Mendelian randomization 
第11週
11/20  Gene expression - eQTL (Transcriptome) 
第12週
11/27  Pathway- & network-based analysis 
第13週
12/04  Functional Genomics 
第14週
12/11  Multi-omic technologies and data sharing/integration/privacy 
第15週
12/18  Metagenomics 
第16週
12/25  Final presentation 
第17週
2020/01/01  New year (holiday) 
第18週
2020/01/08  Final presentation